Publications & Posters
American Journal of Respiratory and Critical Care Medicine | May 2017
Poster Presentation, American Thoracic Society Conference 2017 A.26 Diagnosis and Treatment of Tuberculosis, Poster Session: May 21, 2017
Clinical Immunology | May 31, 2017
Delay in the diagnosis of multiple sclerosis (MS) stems from the lack of specific clinical and analytical markers to assist in the early diagnosis and prediction of progressive course.
Bioanalysis | July 24, 2017
The biomarker bioanalyst now has the tools that are critical to address and resolve the unique biological questions and challenges that exist over the course of the drug development process.
Journal of the American Chemical Society | March 5, 2008
Individual enzyme molecules have been observed to possess discrete and different turnover rates due to the presence of long-lived activity states. If the results reported here can be generalized to other enzymes, then the stochastic nature of individual enzyme molecule kinetics should have a…
Development of (AccuPSA™), a novel digital immunoassay for subfemtomolar measurement of PSA in postradical prostatectomy patients
2011 AACR, Molecular Diagnostics in Cancer Therapeutic Development, Denver, CO
David Wilson1, David Duffy1, David Rissin1, Cheuk Kan1, Todd Campbell1, Stuart Howes1, David Fournier1, Tomasz Piech1, Gail Provuncher1, Purvish Patel1, Evan Ferrell1, Andrew Rivnak1, Jeff Randall1, Linan Song1, David Walt2.1Quanterix Corporation, Cambridge, MA, 2Tufts University, Boston, MA.
Journal of Immunological Methods | April 30, 2012
We have developed a highly sensitive immunoassay—called digital ELISA—that is based on the detection of single enzyme-linked immunocomplexes on beads that are sealed in arrays of femtoliter wells. Digital ELISA was designed to be highly efficient in the capturing of target proteins, labeling of…
Direct Detection of Bacterial DNA and viral RNA at Subfemtomolar Concentrations Using Single Molecule Arrays (Simoa)
2013 Oakridge Conference, Baltimore, MD
Linan Song, Dandan Shan, Mingwei Zhao, Brian A. Pink, Kaitlin A. Minnehan, Lyndsey York, Melissa Gardel, Sean Sullivan, & David C. Duffy Quanterix Corporation, 113 Hartwell Avenue, Lexington, MA 02421, USA
CSF and Plasma Amyloid-b Temporal Profiles and Relationships with Neurological Status and Mortality after Severe Traumatic Brain Injury
Nature Scientific Reports | October 10, 2014
We used ultrasensitive digital ELISA approach to assess amyloid-b1-42 (Ab42) concentrations and time-course in cerebrospinal fluid (CSF) and in plasma of patients with severe TBI and investigated their relationship to injury characteristics, neurological status and clinical outcome.
Brain Research | March 10, 2015
This review on the role of glial fibrillary acidic protein (GFAP) as a biomarker for astroglial pathology in neurological diseases provides background to protein synthesis, assembly, function and degeneration.
Rapid, Fully Automated Digital Immunoassay for p24 Protein with the Sensitivity of Nucleic Acid Amplification for Detecting Acute HIV Infection
2015 American Association for Clinical Chemistry
Carlos Cabrera, Yao Chen, Lei Chang, David H. Wilson Quanterix Corporation, Lexington, MA