Publications & Posters
2011 American Academy of Neurology Annual Meeting, Honolulu, Hawaii
D. Wilson1, E. Mortberg2, S. Rubertsson2, H. Zetterberg3, K. Blennow3, L. Song1, L. Chang1, G. Provuncher1, P. Patel1, E. Ferrell1, D. Fournier1, C. Kan1, T. Campbell1, A. Rivnak1, B. Pink1, K. Minnehan1, T. Piech1, D. Rissin1, D.
Ultra-sensitive protein detection using single molecule arrays (Simoa): the potential for detecting single molecules of botulinum toxin
The Botulinum | 2012
Single molecule arrays (Simoa) make it possible to detect subfemtomolar concentrations of proteins in complex samples. We describe the basis of Simoa and its potential application in the detection of proteins, such as botulinum neurotoxin (BoNT), from pathogenic bacteria. We also provide a concept…
Direct Detection of Bacterial DNA and viral RNA at Subfemtomolar Concentrations Using Single Molecule Arrays (Simoa)
2013 Oakridge Conference, Baltimore, MD
Linan Song, Dandan Shan, Mingwei Zhao, Brian A. Pink, Kaitlin A. Minnehan, Lyndsey York, Melissa Gardel, Sean Sullivan, & David C. Duffy Quanterix Corporation, 113 Hartwell Avenue, Lexington, MA 02421, USA
CSF and Plasma Amyloid-b Temporal Profiles and Relationships with Neurological Status and Mortality after Severe Traumatic Brain Injury
Nature Scientific Reports | October 10, 2014
We used ultrasensitive digital ELISA approach to assess amyloid-b1-42 (Ab42) concentrations and time-course in cerebrospinal fluid (CSF) and in plasma of patients with severe TBI and investigated their relationship to injury characteristics, neurological status and clinical outcome.
Brain Research | March 10, 2015
This review on the role of glial fibrillary acidic protein (GFAP) as a biomarker for astroglial pathology in neurological diseases provides background to protein synthesis, assembly, function and degeneration.
Rapid, Fully Automated Digital Immunoassay for p24 Protein with the Sensitivity of Nucleic Acid Amplification for Detecting Acute HIV Infection
2015 American Association for Clinical Chemistry
Carlos Cabrera, Yao Chen, Lei Chang, David H. Wilson Quanterix Corporation, Lexington, MA
Comparison of three analytical platforms for quantification of the neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and Simoa.
Clinical Chemistry and Laboratory Medicine | April 12, 2016
Neuronal damage is the morphological substrate of persisting neurological disability. Neurofilaments (Nf) are specific cytoskeletal proteins of neurons and their quantification has shown encouraging results as a biomarker for axonal injury.
Evaluation of highly sensitive immunoassay technologies for quantitative measurements of sub-pg/mL levels of cytokines in human serum
Journal of Immunological Methods | August 19, 2016
A comprehensive cross-platform and cross-assay evaluation using nine technology platforms and four cytokine immunoassays (IL-6, TNFα, IL-17a, IL-2) was performed by comparing assay precision, sensitivity, parallelism and data correlation between platforms.
Personalized peptide vaccine-induced immune response associated with long-term survival of a metastatic cholangiocarcinoma patient
Journal of Hepatology | July 2016
Metastatic cholangiocarcinomas, cancers that originate from the liver bile ducts, have very limited treatment options and a fatal prognosis. We describe a novel therapeutic approach in such a patient using a personalized multi-peptide vaccine. This vaccine, developed based on the characterization…
Active duty service members who sustain a traumatic brain injury have chronically elevated peripheral concentrations of Aβ40 and lower ratios of Aβ42/40
Brian Injury | November 11, 2016
Excessive accumulation of amyloid beta (Aβ) and tau have been observed in older individuals with chronic neurological symptoms related to a traumatic brain injury (TBI), yet little is known about the possible role of Aβin younger active duty service members following a TBI. The purpose of the study…