Publications & Posters

Publications & Posters

Clinical Chemistry and Laboratory Medicine | October 23, 2015
The cerebrospinal fluid (CSF) amyloid-β (Aβ42) peptide is an important biomarker for Alzheimer's disease (AD). Variability in measured Aβ42 concentrations at different laboratories may be overcome by standardization and establishing traceability to a reference system. Candidate certified reference…
Journal of Clinical Microbiology | February 1, 2016
Recently developed ultrasensitive and quantitative methods for detection of Clostridium difficile toxins provide new tools for diagnosis and, potentially, for management of C. difficile infection (CDI). Compared to methods that detect toxigenic organism, ultrasensitive toxin detection may allow…
EMBO Molecular Medicine | April 14, 2016
Biochemical experiments, animal models, and observational studies in humans all support a role of dipeptidyl peptidase 4 (DPP4) in the N-terminal truncation of CXCL10, which results in the generation of an antagonist form of the chemokine that limits T-cell and NK cell migration. This study…
Analytical Biochemistry | July 4, 2016
This study focuses on the inhibition of the autophagy initiating kinase ULK1 by measuring the both total Atg13 and the phosphorylation of Atg13(pSer318) from control and following compound treatment in either overexpressing or wild type tissue culture samples.
Journal of Neurotrauma | August 19, 2016
Diffuse axonal injury (DAI) is an important cause of morbidity in patients with traumatic brain injury (TBI). There is a lack of a simple and reliable technique to early identify patients with DAI and to prognosticate long-term outcome in this patient group.
Hospital Medicine Clinics | October, 2016
Troponin is an intracellular regulatory protein complex associated with the contractile apparatus of skeletal and cardiac myocytes. Irreversible injury of cardiac myocytes leading to cell death (myocardial necrosis) results in the release of cTnI and cTnT into the circulation. Highly specific…
Nature Communications | December 2016
Interstitial fibrosis plays a key role in the development and progression of heart failure. Here, we show that an enzyme that crosslinks collagen-Lysyl oxidase-like 2 (Loxl2)-is essential for interstitial fibrosis and mechanical dysfunction of pathologically stressed hearts. In mice, cardiac stress…
Neurology | January 6, 2017
Despite the 3.8 million sports-related concussions (SRC) that occur annually in the United States, there are currently no prognostic biomarkers to predict recovery and an athlete’s readiness to return to play (RTP). An objective predictor of recovery time in the acute aftermath of SRC would provide…
ACS Applied Materials & Interfaces | March 7, 2017
Bead-based microwell array technology is growing as an ultrasensitive analysis tool as exemplified by the successful commercial applications from Illumina and Quanterix for nucleic acid analysis and ultrasensitive protein measurements, respectively.
Journal of Immunological Methods | April 5, 2017
The aim of this study was to develop and validate a Rhodopsin assay by employing digital ELISA technology, and to investigate whether Rhodopsin concentrations in diabetes patients with DR are elevated compared with diabetes patients without DR.