Publications & Posters
Ultrasensitive detection of neurodegenerative biomarkers in blood with the fully automated Simoa analyzer
2014 AAIC, Copenhagen, Denmark
Andreas Jeromin,1 Jeffrey Randall,1 David H. Wilson,1 Kaj Blennow2, Henrik Zetterberg2,3
AAPS Journal | January 2015
Ligand binding assays (LBAs) have been the method of choice for protein analyte measurements for more than four decades. Over the years, LBA methods have improved in sensitivity and achieved larger dynamic ranges by using alternative detection systems and new technologies.
The Simoa HD-1 Analyzer A Novel Fully Automated Digital Immunoassay Analyzer with Single-Molecule Sensitivity and Multiplexing
Journal of Laboratory Automation | June 15, 2015
The potential of digital immunoassays to advance human diagnostics was illustrated in two clinical areas: traumatic brain injury and early detection of infectious disease.
Fully Automated Ultrasensitive Digital Immunoassay for Cardiac Troponin I Based on Single Molecule Array Technology
Clinical Chemistry | August 17, 2015
The association between increases in cardiac troponin and adverse cardiac outcomes is well established. There is a growing interest in exploring routine cardiac troponin monitoring as a potential early indicator of adverse heart health trends. Prognostic use of cardiac troponin measurements…
Human Brain Mapping | December 2015
There is great interest in developing physiological-based biomarkers such as diffusion tensor imaging to aid in the management of concussion, which is currently entirely dependent on clinical judgment. However, the time course for recovery of white matter abnormalities following sports-related…
Development of an ultra-sensitive Simoa assay to enable GDF11 detection: a comparison across bioanalytical platforms
Bioanalysis | February 26, 2016
Four bioanalytical platforms were evaluated to optimize sensitivity and enable detection of recombinant human GDF11 in biological matrices. Simoa achieved the greatest sensitivity, an improvement of 100-fold over the next sensitive platform.
Alzheimer’s & Dementia | May 24, 2016
Alzheimer disease (AD) and Parkinson disease (PD) involve tau pathology. Tau is detectable in blood, but its clearance from neuronal cells and the brain is poorly understood.
Rapid and ultrasensitive detection of botulinum neurotoxin serotype A1 in human serum and urine using single-molecule array method
Forensic Toxicology | September 2, 2016
Botulinum neurotoxin is one of the most poisonous substances ever known. It causes botulism, a persistent paralysis of peripheral nerve termini.
Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition
Alzheimer’s & Dementia | October 14, 2016
Long-term BACE1 inhibition prevents CSF tau increase both in early-depositing APP transgenic mice and APP transgenic mice with moderate Aβ pathology.
Cell Reports | January 31, 2017
The presence of latent HIV-1 in infected individuals represents a major barrier preventing viral eradication. For that reason, reactivation of latent viruses in the presence of antiretroviral regimens has been proposed as a therapeutic strategy to achieve remission.