Publications & Posters
Development of an ultra-sensitive Simoa assay to enable GDF11 detection: a comparison across bioanalytical platforms
Bioanalysis | February 26, 2016
Four bioanalytical platforms were evaluated to optimize sensitivity and enable detection of recombinant human GDF11 in biological matrices. Simoa achieved the greatest sensitivity, an improvement of 100-fold over the next sensitive platform.
Alzheimer’s & Dementia | May 24, 2016
Alzheimer disease (AD) and Parkinson disease (PD) involve tau pathology. Tau is detectable in blood, but its clearance from neuronal cells and the brain is poorly understood.
Rapid and ultrasensitive detection of botulinum neurotoxin serotype A1 in human serum and urine using single-molecule array method
Forensic Toxicology | September 2, 2016
Botulinum neurotoxin is one of the most poisonous substances ever known. It causes botulism, a persistent paralysis of peripheral nerve termini.
Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition
Alzheimer’s & Dementia | October 14, 2016
Long-term BACE1 inhibition prevents CSF tau increase both in early-depositing APP transgenic mice and APP transgenic mice with moderate Aβ pathology.
Cell Reports | January 31, 2017
The presence of latent HIV-1 in infected individuals represents a major barrier preventing viral eradication. For that reason, reactivation of latent viruses in the presence of antiretroviral regimens has been proposed as a therapeutic strategy to achieve remission.
Regulated Bioanalysis: Fundamentals and Practice | April 26, 2017
Johanna Mora, Charles Hottenstein, Binodh DeSilvaRegulated Bioanalysis: Fundamentals and Practice Volume 26 of the series AAPS Advances in the Pharmaceutical Sciences series
Neurology and Therapy | July 21, 2017
A set of core cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) includes total tau (T-tau), phosphorylated tau (P-tau) and β-amyloid 42 (Aβ42).
Development of an Ultra-Sensitive Digital Immunoassay (Simoa®) to Detect PSD-95 in Cerebrospinal Fluid (CSF) and Brain Lysate
2018 AAIC, CHICAGO, IL Mary Brock(1), B.S., Linan Song(1), Ph.D, Mingwei Zhao, Ph.D(1), David Hanlon(1), Ph.D, Julie Czerkowicz(2), M.A., Danielle Graham(2), Ph.D. (1) Quanterix Corporation, Lexington, MA, USA (2) Biogen, Cambridge, MA, USA
Science Translational Medicine
Fadlallah J, El Kafsi H, Sterlin D, Juste C, Parizot C, Dorgham K, Autaa G, Gouas D, Almeida M, Lepage P, Pons N, Le Chatelier E, Levenez F, Kennedy S, Galleron N, de Barros JP, Malphettes M, Galicier L, Boutboul D, Mathian A, Miyara M, Oksenhendler E, Amoura Z, Dore J, Fieschi C, Ehrlich SD, Lar
Digital Readout of Target Binding with Attomole Detection Limits via Enzyme Amplification in Femtoliter Arrays
Journal of the American Chemical Society | April 20, 2006
In this communication, single molecules of β-galactosidase were captured on a 1 mm femtoliter array using biotin−streptavidin binding.