Determining whether sports-related concussion is associated with elevated levels of blood biochemical markers of injury to the central nervous system and to assess whether plasma levels of these biomarkers predict return to play in professional ice hockey players with sports-related concussion
Publications & Posters
JAMA Neurology | March 13, 2014
Clinical Chemistry and Laboratory Medicine | October 22, 2014
Immunoassays measuring cardiac troponins I or T have become firmly established as critical tools for diagnosing acute myocardial infarction.
Single molecule array glial fibrillary acid protein and tau are increased in plasma after traumatic brain injury
2015 National Capital Area TBI Research Symposium, Bethesda, MD
T. Bogoslovsky, MD, PhD, D. Wilson, PhD, Y. Chen, PhD, D. Hanlon, PhD, J. Gill2, PhD, A. Jeromin, PhD, Y. Gong, MD, K. Kenney, MD, C. Moore, MA, R. Diaz-Arrastia MD, PhD Center for Neuroscience and Regenerative Medicine and National Institute of Neurological Disorders and Stroke
High-Sensitivity Immunoassays for IVD Applications: Evaluation of the Analytical Performance Characteristics of the Simoa HD-1 Automated Platform
2015 American Association for Clinical Chemistry
V. Benoit, B. Seignères, M. Lesénéchal, N. Cayet, C. Tourneur, M. Richard, M.C. Bastide, C. Pretis, C. Pease, B. Beyaert, J.M. Dugua, M. Hausmann bioMérieux S.A., Marcy l’Etoile, France
Assessing the commutability of reference material formats for the harmonization of amyloid beta measurements
Clinical Chemistry and Laboratory Medicine | October 23, 2015
The cerebrospinal fluid (CSF) amyloid-β (Aβ42) peptide is an important biomarker for Alzheimer's disease (AD). Variability in measured Aβ42 concentrations at different laboratories may be overcome by standardization and establishing traceability to a reference system. Candidate certified reference…
Ultrasensitive Detection and Quantification of Toxins for Optimized Diagnosis of Clostridium difficile Infection.
Journal of Clinical Microbiology | February 1, 2016
Recently developed ultrasensitive and quantitative methods for detection of Clostridium difficile toxins provide new tools for diagnosis and, potentially, for management of C. difficile infection (CDI). Compared to methods that detect toxigenic organism, ultrasensitive toxin detection may allow…
Inhibition of DPP4 activity in humans establishes its in vivo role in CXCL10 post-translational modification: prospective placebo-controlled clinical studies
EMBO Molecular Medicine | April 14, 2016
Biochemical experiments, animal models, and observational studies in humans all support a role of dipeptidyl peptidase 4 (DPP4) in the N-terminal truncation of CXCL10, which results in the generation of an antagonist form of the chemokine that limits T-cell and NK cell migration. This study…
An ultrasensitive assay format for detecting ULK1 inhibition by monitoring the phosphorylation status of Atg13
Analytical Biochemistry | July 4, 2016
This study focuses on the inhibition of the autophagy initiating kinase ULK1 by measuring the both total Atg13 and the phosphorylation of Atg13(pSer318) from control and following compound treatment in either overexpressing or wild type tissue culture samples.
Serum neurofilament light protein as a marker for diffuse axonal injury - results from a case series study
Journal of Neurotrauma | August 19, 2016
Diffuse axonal injury (DAI) is an important cause of morbidity in patients with traumatic brain injury (TBI). There is a lack of a simple and reliable technique to early identify patients with DAI and to prognosticate long-term outcome in this patient group.
Hospital Medicine Clinics | October, 2016
Troponin is an intracellular regulatory protein complex associated with the contractile apparatus of skeletal and cardiac myocytes. Irreversible injury of cardiac myocytes leading to cell death (myocardial necrosis) results in the release of cTnI and cTnT into the circulation. Highly specific…