David H. Wilson, Cheuk W. Kan, Andrew J. Rivnak, Todd G. Campbell, Tomasz Piech, David M. Rissin, Purvish P. Patel, Evan P. Ferrell, Erica Frew, Gail Provuncher, Alfred Schroff, Raymond E. Meyer, Mathew Fishburn, Lei Chang, David R. Fournier, and David C. Duffy
Publications & Posters
Simoa HD-1: a fully automated digital immunoassay analyzer capable of single molecule counting, sub-femtomolar sensitivity, and multiplexing
2014 AACC, Chicago, IL
Stoichiometry of the α‑Complementation Reaction of Escherichia coli β‑Galactosidase As Revealed through Single-Molecule Studies
Biochemistry | February 10, 2015
The α-complementation reaction of β-galactosidase was studied at single-molecule resolution using arrays of femtoliter-sized wells.
Dynamic Changes of Post-Translationally Modified Forms of CXCL10 and Soluble DPP4 in HCV Subjects Receiving Interferon-Free Therapy
PLOS ONE | July 16, 2015
Serum levels of the interferon (IFN)-stimulated chemokine CXCL10 are increased during chronic HCV infection and associate with outcome of IFN-based therapy.
Nature Neuroscience | September 9, 2015
Cerebral β-amyloidosis is induced by inoculation of Aβ seeds into APP transgenic mice, but not into App−/− (APP null) mice. We found that brain extracts from APP null mice that had been inoculated with Aβ seeds up to 6 months previously still induced β-amyloidosis in APP transgenic hosts following…
Immunochemistry for high-throughput screening of human exhaled breath condensate (EBC) media: implementation of automated Quanterix SIMOA instrumentation
Journal of Breath Research| December 11, 2015
Immunochemistry is an important clinical tool for indicating biological pathways leading towards disease. Standard enzyme-linked immunosorbent assays (ELISA) are labor intensive and lack sensitivity at low-level concentrations. Here we report on emerging technology implementing fully automated…
Scientific Reports | May 31, 2016
Implementation of amyloid biomarkers in clinical practice would be accelerated if such biomarkers could be measured in blood. This study analyzes plasma levels of Aβ42 and Aβ40 in a cohort of 719 individuals using a ultrasensitive Simoa platform.