Using an in vitro model of HIV-infected quiescent CD4 T cells, we reveal a gene expression signature of 103 upregulated genes that are specific for latently infected cells
Publications & Posters
Nature | March 15, 2017
Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10
The Journal of Immunology | April 7, 2017
In this study, we report that oral administration of a selective ROCK2 inhibitor, KD025, reduces psoriasis area and severity index scores by 50% from baseline in 46% of patients with psoriasis vulgaris, and it decreases epidermal thickness as well as T cell infiltration in the skin.
Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy
Science Translational Medicine | April 19, 2017
Tauopathies are a group of disorders in which the cytosolic protein tau aggregates and accumulates in cells within the brain, resulting in neurodegeneration. A promising treatment being explored for tauopathies is passive immunization with anti-tau antibodies.
Multiple Sclerosis Journal| May 24, 2017
Neurodegeneration plays a key role in multiple sclerosis (MS) contributing to long-term disability in patients. The prognosis is, however, unpredictable coloured by complex disease mechanisms which can only be clearly appreciated using biomarkers specific to pathobiology of the underlying process.
Nucleic Acids Research | June 20, 2017
The high sensitivity and simple workflow of the Simoa method represent excellent advantages for miRNA-based diagnostics of human diseases.
Development of a 4-Plex Digital Immunoassay for Detection of Neurofilament-Light, Tau, Glial Fibrillary Acidic Protein and Ubiquitin c-Terminal Hydrolase L1 in Blood and Cerebrospinal Fluid.
Neurofilament Light Chain (NF-Light), Tau, Glia Fibrillary Acidic Protein (GFAP) and Ubiquitin c-Terminal Hydrolase L1 (UCH-L1) are emerging neurology biomarkers relevant for neurodegeneration and traumatic brain injury. Simultaneous measurement of NF-Light, Tau, GFAP and UCH-L1 in serum, plasma,…
JCI Insight |August 17, 2017
Promising therapeutic approaches for eradicating HIV include transcriptional activation of provirus from latently infected cells using latency-reversing agents (LRAs) and immune-mediated clearance to purge reservoirs. Accurate detection of cells capable of producing viral antigens and virions, and…
Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations
Nature Biotechnology | May 23, 2010
The ability to detect single protein molecules in blood could accelerate the discovery and use of more sensitive diagnostic biomarkers. To detect low-abundance proteins in blood, we captured them on microscopic beads decorated with specific antibodies and then labeled the immunocomplexes (one or…
2011 Neuroscience, Washington, DC
J.D. Randall,1 H. Zetterberg,3 E. Mortberg,2 S. Rubertsson,2 G. Provuncher,1 P. Patel,1 E. Ferrell,1 D. Fournier,1 C. Kan,1 T. Campbell,1 A. Rivnak,1 B. Pink,1 K. Minnehan,1 T. Piech,1 D. Duffy,1K. Blennow,3D. Wilson1
Direct Detection of Bacterial Genomic DNA at Sub-Femtomolar Concentrations Using Single Molecule Arrays
Analytical Chemistry | January 18, 2013
We report a method for the sensitive measurement of genomic DNA based on the direct detection of single molecules of DNA in arrays of femtoliter wells.