Publications & Posters
Brain Injury | March 8, 2013
The aim of this study was to investigate if olympic (amateur) boxing is associated with elevation of brain injury biomarkers in peripheral blood compared to controls.
Analytical Chemistry | April 1, 2014
As analytical chemists, the highest resolution measurement one can make is at the single molecule level; it just does not get any better than that.
Molecules | September 12, 2014
Large arrays of homogeneous microwells each defining a femtoliter volume are a versatile platform for monitoring the substrate turnover of many individual enzyme molecules in parallel. Here, we introduce recent progress in single enzyme molecule analysis in microwell arrays and discuss the…
Journal of Clinical Microbiology | February 25, 2015
We developed a simple immunoassay capable of differentially detecting toxin B from highly virulent strains of Clostridium difficile (BI/NAP-1/027) in stool. This assay can simultaneously confirm the presence of in vivo toxin production and provide strain-related information relevant to infection…
Fully automated ultrasensitive digital immunoassay for troponin using single molecule array technology
2015 American Association for Clinical Chemistry
P. Patel , D. Shan , L. Styskal , L. Chang , D. H. Wilson , M. J. Conrad , P. Jarolim Quanterix Corporation, Lexington, MA, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Rapid, Fully Automated Digital Immunoassay for p24 Protein with the Sensitivity of Nucleic Acid Amplification for Detecting Acute HIV Infection
Clinical Chemistry | September 14, 2015
Nucleic acid testing (NAT) has become the standard for high sensitivity in detecting low levels of virus. However, adoption of NAT can be cost prohibitive in low-resource settings where access to extreme sensitivity could be clinically advantageous for early detection of infection. We report…
Levels of tau protein in plasma are associated with neurodegeneration and cognitive function in a population-based elderly cohort
Alzheimer's and Dementia |2016
Tau protein levels in plasma may be a marker of neuronal damage. We examined associations between plasma tau levels and Alzheimer's disease (AD)–related magnetic resonance imaging (MRI) and positron emission tomography (PET) neuroimaging measures among nondemented individuals.
Annals of Clinical and Translational Neurology | March 3, 2016
Blood‐based biomarkers for neurodegenerative conditions could improve diagnosis and treatment development. Neurofilament light chain (NfL), a marker of axonal injury, is elevated in cerebrospinal fluid (CSF) of patients with progressive supranuclear palsy (PSP). The goal of this study was to…
Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders
Analytical Biochemistry | June 25, 2016
This study focuses on the inhibition of the autophagy initiating kinase ULK1 by measuring the both total Atg13 and the phosphorylation of Atg13(pSer318) from control and following compound treatment in either overexpressing or wild type tissue culture samples.
Incorporation of Slow Off-Rate Modified Aptamers Reagents in Single Molecule Array Assays for Cytokine Detection with Ultrahigh Sensitivity
Analytical Chemistry |August 16, 2016
Danlu Wu, Evaldas Katilius, Edgar Olivas, Milena Dumont Milutinovic, and David R. WaltAnalytical Chemistry DOI: 10.1021/acs.analchem.6b02451