In this communication, single molecules of β-galactosidase were captured on a 1 mm femtoliter array using biotin−streptavidin binding.
Publications & Posters
Digital Readout of Target Binding with Attomole Detection Limits via Enzyme Amplification in Femtoliter Arrays
Journal of the American Chemical Society | April 20, 2006
Digital Concentration Readout of Single Enzyme Molecules Using Femtoliter Arrays and Poisson Statistics
Nano Letters| February 21, 2006
Methods for accurately quantifying the concentration of a particular analyte in solution are all based on ensemble responses in which many analyte molecules give rise to the measured signal.