Publications & Posters

Publications & Posters

Nature Scientific Reports | October 10, 2014
We used ultrasensitive digital  ELISA approach to assess amyloid-b1-42 (Ab42) concentrations and time-course in cerebrospinal fluid (CSF) and in plasma of patients with severe TBI and investigated their relationship to injury characteristics, neurological status and clinical outcome.
Molecules | September 12, 2014
Large arrays of homogeneous microwells each defining a femtoliter volume are a versatile platform for monitoring the substrate turnover of many individual enzyme molecules in parallel. Here, we introduce recent progress in single enzyme molecule analysis in microwell arrays and discuss the…
Journal of the American Chemical Society | September 8, 2014
In this paper, we describe a microdose-scale injectable formulation of nanoparticles that interrogate the activity of thrombin, a key regulator of clotting, and produce urinary reporters of disease state.
2014 AACC, Chicago, IL
David H. Wilson, Cheuk W. Kan, Andrew J. Rivnak, Todd G. Campbell, Tomasz Piech, David M. Rissin, Purvish P. Patel, Evan P. Ferrell, Erica Frew, Gail Provuncher, Alfred Schroff, Raymond E. Meyer, Mathew Fishburn, Lei Chang, David R. Fournier, and David C. Duffy
2014 AAIC, Copenhagen, Denmark
Andreas Jeromin,1 Jeffrey Randall,1 David H. Wilson,1 Kaj Blennow2, Henrik Zetterberg2,3
Lab on a Chip | May 2, 2014
Protein measurements are essential to many fields ranging from fundamental biochemistry to clinical diagnostics. The ability to make measurements of proteins with ultra-sensitivity will enable early diagnosis of diseases by accessing a concentration regime below the detection limit of present…
2014 Traumatic Brain Injury Conference, Washington, DC
Andreas Jeromin1*, Jeffrey Randall1, David H Wilson1, Kaj Blennow2, Henrik Zetterberg2,3
JAMA Neurology | March 13, 2014
Determining whether sports-related concussion is associated with elevated levels of blood biochemical markers of injury to the central nervous system and to assess whether plasma levels of these biomarkers predict return to play in professional ice hockey players with sports-related concussion
PLOS One | January 24, 2014 | January 21, 2014
In this paper, we demonstrate that single enzyme molecules of β-galactosidase interconvert between different activity states upon exposure to short pulses of heat. We show that these changes in activity are the result of different enzyme conformations. Hundreds of single β-galactosidase molecules…
Analytical Chemistry | April 1, 2014
As analytical chemists, the highest resolution measurement one can make is at the single molecule level; it just does not get any better than that.