Publications & Posters
Single molecule array glial fibrillary acid protein and tau are increased in plasma after traumatic brain injury
2015 National Capital Area TBI Research Symposium, Bethesda, MD
T. Bogoslovsky, MD, PhD, D. Wilson, PhD, Y. Chen, PhD, D. Hanlon, PhD, J. Gill2, PhD, A. Jeromin, PhD, Y. Gong, MD, K. Kenney, MD, C. Moore, MA, R. Diaz-Arrastia MD, PhD Center for Neuroscience and Regenerative Medicine and National Institute of Neurological Disorders and Stroke
Brain Research | March 10, 2015
This review on the role of glial fibrillary acidic protein (GFAP) as a biomarker for astroglial pathology in neurological diseases provides background to protein synthesis, assembly, function and degeneration.
Journal of Clinical Microbiology | February 25, 2015
We developed a simple immunoassay capable of differentially detecting toxin B from highly virulent strains of Clostridium difficile (BI/NAP-1/027) in stool. This assay can simultaneously confirm the presence of in vivo toxin production and provide strain-related information relevant to infection…
Single Molecule Arrays (Simoa) for the Ultra-Sensitive Detection of the Host Immune Response to Dengue Infection
Journal of Clinical Microbiology | February 18, 2015
Dengue positive plasma was applied to an indirect single molecule array (Simoa) for the detection of anti-dengue IgG and IgM. The Simoas were 1,000 and 10,000 times more sensitive than ELISAs, respectively. Using Simoa, serology may be used for the detection of dengue infection in the acute phase
Stoichiometry of the α‑Complementation Reaction of Escherichia coli β‑Galactosidase As Revealed through Single-Molecule Studies
Biochemistry | February 10, 2015
The α-complementation reaction of β-galactosidase was studied at single-molecule resolution using arrays of femtoliter-sized wells.
AAPS Journal | January 2015
Ligand binding assays (LBAs) have been the method of choice for protein analyte measurements for more than four decades. Over the years, LBA methods have improved in sensitivity and achieved larger dynamic ranges by using alternative detection systems and new technologies.
A new ultra-high sensitivity troponin I assay for chest pain patients with no evidence of troponin I using a conventional assay
Clinical Biochemistry | December 4, 2014
There is considerable clinical interest in the development and possible implementation of highly sensitive cardiac troponin I (cTnI) assays for early rule out of acute coronary syndromes, short-term (30 days) risk stratification for future adverse cardiac events, and for detecting cardiac injury…
2014 AAPS, San Diego, CA
Michael Tanen, Russell Weiner, Omar Laterza Molecular Biomarkers & Diagnostics, Merck Research Laboratories, Rahway NJ 07065
Clinical Chemistry and Laboratory Medicine | October 22, 2014
Immunoassays measuring cardiac troponins I or T have become firmly established as critical tools for diagnosing acute myocardial infarction.
CSF and Plasma Amyloid-b Temporal Profiles and Relationships with Neurological Status and Mortality after Severe Traumatic Brain Injury
Nature Scientific Reports | October 10, 2014
We used ultrasensitive digital ELISA approach to assess amyloid-b1-42 (Ab42) concentrations and time-course in cerebrospinal fluid (CSF) and in plasma of patients with severe TBI and investigated their relationship to injury characteristics, neurological status and clinical outcome.