Publications & Posters
Next Generation Ligand Binding Assays—Review of Emerging Technologies’ Capabilities to Enhance Throughput and Multiplexing
American Association of Pharmaceutical Scientists | November 2014
The purpose of this manuscript is to provide a summary of the evaluation done by the Throughput and Multiplexing subteam on five emerging technologies: Single molecule array (Simoa™), Optimiser™, CyTOF® (Mass cytometry), SQIDLite™, and iLite™.
Journal of the American Chemical Society | September 8, 2014
In this paper, we describe a microdose-scale injectable formulation of nanoparticles that interrogate the activity of thrombin, a key regulator of clotting, and produce urinary reporters of disease state.
Single Molecule Arrays (Simoa) for the Ultra-Sensitive Detection of the Host Immune Response to Dengue Infection
Journal of Clinical Microbiology | February 18, 2015
Dengue positive plasma was applied to an indirect single molecule array (Simoa) for the detection of anti-dengue IgG and IgM. The Simoas were 1,000 and 10,000 times more sensitive than ELISAs, respectively. Using Simoa, serology may be used for the detection of dengue infection in the acute phase
Fully Automated Ultrasensitive Digital Immunoassay for Cardiac Troponin I Based on Single Molecule Array Technology
Clinical Chemistry | August 17, 2015
The association between increases in cardiac troponin and adverse cardiac outcomes is well established. There is a growing interest in exploring routine cardiac troponin monitoring as a potential early indicator of adverse heart health trends. Prognostic use of cardiac troponin measurements…