Publications & Posters
Circulation | American Heart Association | November 14, 2017
Relations between elevated circulating cardiac troponin I (cTnI) levels and adverse cardiac outcomes were established prior to the advent of methods to measure extremely low levels of cTnI. Recently developed ELISA assays/platforms with ultra-high sensitivity cTnI (u-hs-cTnI) allow accurate…
Prognostic utility of neuroinjury biomarkers in post out-of-hospital cardiac arrest (OHCA) patient management
Medical Hypotheses | August 2017
Despite aggressive intervention, patients who survive an out-of-hospital cardiac arrest (OHCA) generally have very poor prognoses, with nationwide survival rates of approximately 10–20%.
Nature Communications | December 2016
Interstitial fibrosis plays a key role in the development and progression of heart failure. Here, we show that an enzyme that crosslinks collagen-Lysyl oxidase-like 2 (Loxl2)-is essential for interstitial fibrosis and mechanical dysfunction of pathologically stressed hearts. In mice, cardiac stress…
Hospital Medicine Clinics | October, 2016
Troponin is an intracellular regulatory protein complex associated with the contractile apparatus of skeletal and cardiac myocytes. Irreversible injury of cardiac myocytes leading to cell death (myocardial necrosis) results in the release of cTnI and cTnT into the circulation. Highly specific…
Scientific Reports | May 31, 2016
Implementation of amyloid biomarkers in clinical practice would be accelerated if such biomarkers could be measured in blood. This study analyzes plasma levels of Aβ42 and Aβ40 in a cohort of 719 individuals using a ultrasensitive Simoa platform.
Fully Automated Ultrasensitive Digital Immunoassay for Cardiac Troponin I Based on Single Molecule Array Technology
Clinical Chemistry | August 17, 2015
The association between increases in cardiac troponin and adverse cardiac outcomes is well established. There is a growing interest in exploring routine cardiac troponin monitoring as a potential early indicator of adverse heart health trends. Prognostic use of cardiac troponin measurements…
Fully automated ultrasensitive digital immunoassay for troponin using single molecule array technology
2015 American Association for Clinical Chemistry
P. Patel , D. Shan , L. Styskal , L. Chang , D. H. Wilson , M. J. Conrad , P. Jarolim Quanterix Corporation, Lexington, MA, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
A new ultra-high sensitivity troponin I assay for chest pain patients with no evidence of troponin I using a conventional assay
Clinical Biochemistry | December 4, 2014
There is considerable clinical interest in the development and possible implementation of highly sensitive cardiac troponin I (cTnI) assays for early rule out of acute coronary syndromes, short-term (30 days) risk stratification for future adverse cardiac events, and for detecting cardiac injury…
Clinical Chemistry and Laboratory Medicine | October 22, 2014
Immunoassays measuring cardiac troponins I or T have become firmly established as critical tools for diagnosing acute myocardial infarction.
2013 AACC Meeting, Houston, TX
L. Chang1, P. Patel1, L. Song1, Y. Chen1, D. Hanlon1, K. Minnehan1, M. Gardel1, B. Pink1, L. York1, S. Sullivan1, R. Meyer1, B. Flaherty1, J. Christopher1, D. H. Wilson1, M.J. Conrad,2 P.