This study used an ultrasensitive single molecule methodology to measure plasma tau concentrations in 176 participants: 71 with bvFTD, 83 with PPA and 22 healthy controls.
Publications & Posters
Journal of Neurology, Neurosurgery & Psychiatry | February 13, 2018
Valproic Acid Treatment Decreases Serum GFAP and UCH‐L1 Levels in Swine Subjected to Traumatic Brain Injury
Journal of Neurotrauma | February 07, 2018
The primary aim of this study was to examine the effects of valproic acid (VPA) treatment on serum glial fibrillary acidic protein (GFAP) and neurofilament light chain (NF-L) levels.
Neurology | January 24, 2018
Neurofilament light (NfL) protein in blood plasma has been proposed as a prognostic biomarker of neurodegeneration in a number of conditions, including Huntington disease (HD). This study investigates the regional distribution of NfL-associated neural pathology in HD gene expansion carriers.
Neurology | January 10, 2018
The objective of this study was to perform a cross-sectional study to determine whether plasma neurofilament light chain (NfL) concentration is elevated in patients with Charcot-Marie-Tooth disease (CMT) and if it correlates with disease severity.
Neurology | January 02, 2018
Study objective was to examine neurofilament (Nf) concentrations according to symptom onset and clinical diagnostic certainty categories of amyotrophic lateral sclerosis (ALS).
European Journal of Neurology | December 27, 2017
Serum Neurofilaments are markers of axonal injury. We addressed their diagnostic and prognostic role in acute ischemic stroke (AIS) and TIA.
Neurology | December 27, 2017
The study objective was to determine the ability of CSF biomarkers to predict disease progression in progressive supranuclear palsy (PSP).
BRain health and healthy AgeINg in retired rugby union players, the BRAIN Study: study protocol for an observational study in the UK
BMJ Open | December 26, 2017
There is currently limited but increasing evidence that poorer age-related and neurological health exists among former professional sportsmen exposed to repetitive concussions; however the evidence is limited on rugby union players, specifically.
Minocycline reduces chronic microglial activation after brain trauma but increases neurodegeneration
Brain | December 19, 2017
Survivors of a traumatic brain injury can deteriorate years later, developing brain atrophy and dementia. Traumatic brain injury triggers chronic microglial activation, but it is unclear whether this is harmful or beneficial. A successful chronic-phase treatment for traumatic brain injury might be…
Age at injury and genotype modify acute inflammatory and neurofilament-light responses to mild CHIMERA traumatic brain injury in wild-type and APP/PS1 mice
Experimental Neurology | December 18, 2017
Peak incidence of traumatic brain injury (TBI) occurs in both young and old individuals, and older age at injury is associated with worse outcome and poorer recovery. Moderate-severe TBI is a reported risk factor for dementia, including Alzheimer's disease (AD), but whether mild TBI (mTBI) alters…