The objective of this study was to clinically validate a new ultra-sensitive immunoassay platform with EDTA plasma patient specimens for eventual translation as a blood-based biomarker in immuno-oncology.
Publications & Posters
48 Single Molecule Array Ultra-Sensitive Cytokine Assays in EDTA Plasma Are Robust and Clinically Feasible
American Journal of Clinical Pathology | January 11, 2018
Molecular Immunology | January 08, 2018
Sensitivity of assays for detection of low abundance proteins have been improved by orders of magnitude based on unique properties of nanomaterials.
AAPS Journal | December 01, 2017
An in-depth evaluation of the Quanterix© Simoa™ platform was undertaken by scientists from the AAPS Emerging Technologies Focus Group to determine the overall performance of the technology as well as provide guidance to future users.
BIOANALYSIS | November 09, 2017
Editorial discussing analytical assessments of immunogenicity and biomarkers
Journal of Immunological Methods | November 06, 2017
Results from the study suggest that sweat patches are a feasible method to collect cytokine data from older adults.
Journal of Immunological Methods | October 17, 2017
The ability to measure cytokines present at low concentrations in rat serum will facilitate future studies of disease using rats as animal models.
GEN | October 15, 2017
The future of immuno-oncology treatment and autoimmune diagnostics will involve the detection and quantification of inflammatory biomarkers. As immunotherapy becomes a more common approach for treating cancer and inflammatory disease, cytokines will not only play a role in determining a patient’s…
Long-Term Measurements of Human Inflammatory Cytokines Reveal Complex Baseline Variations between Individuals
THE AMERICAN JOURNAL OF PATHOLOGY | September 15, 2017
Many important protein biomarkers, such as cytokines, exist at extremely low or undetectable levels in the healthy state. This paper describes results from a 14-week study of healthy human subjects using ultrasensitive single molecule array (Simoa) assays to measure both intra and intersubject…
Bioanalysis | July 24, 2017
The biomarker bioanalyst now has the tools that are critical to address and resolve the unique biological questions and challenges that exist over the course of the drug development process.
Polymerase-free measurement of microRNA-122 with single base specificity using single molecule arrays: Detection of drug-induced liver injury
PLOS ONE | July 5, 2017
We have developed a single probe method for detecting microRNA from human serum using single molecule arrays, with sequence specificity down to a single base, and without the use of amplification by polymerases.