Pase MP, Himali JJ, Aparicio HJ, Romero JR, Satizabal CL, Maillard P, DeCarli C, Beiser AS and Seshadri S.
Ann Neurol. 2019 Jul 4. doi: 10.1002/ana.25542
Higher plasma total-tau level is associated with incident dementia but its relationship with stroke risk is unknown. In this prospective community-based study, we evaluated plasma total-tau level as a biomarker of stroke risk in 2794 Framingham Heart Study participants. Persons with plasma total-tau levels in the top quintile, versus the bottom four, had an increased risk of incident stroke over a mean follow-up of 8.3 years (Hazard Ratio, 2.01; 95% Confidence Interval, 1.32-3.08) following adjustments for age, sex, and stroke risk factors. Our findings demonstrate that plasma total-tau relates to the risk of stroke in a community sample. This article is protected by copyright. All rights reserved.