Neurofilament light chain as an indicator of exacerbation prior to clinical symptoms in multiple sclerosis.

Multiple Sclerosis and Related Disorders
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Edwards KR, Garten L, Button J, O'Connor J, Kamath V and Frazier C.

Mult Scler Relat Disord. 2019 Mar 23;31:59-61.

DOI: 10.1016/j.msard.2019.03.016

BACKGROUND:

Biomarkers may be a sensitive measure of disease activity in patients with multiple sclerosis (pwMS).

OBJECTIVE:

A pwMS had a marked increase of neurofilament light chain (NfL) in CSF 9-weeks prior to a clinical exacerbation.

METHODS AND RESULTS:

Brain MRI, CSF, EDSS were measured at baseline, 6 weeks and 28 weeks. The patient had an exacerbation at week 15 of study but the NfL measured at week 6 were found to show a nearly 3-fold increase of CSF NfL levels prior to symptoms when the NfL levels were later measured.

CONCLUSION:

This is an example supporting the usefulness of NfL in monitoring disease activity in pwMS which may predict disease activity prior to a clinical exacerbation.