Neurofilament light chain as an indicator of exacerbation prior to clinical symptoms in multiple sclerosis.

Multiple Sclerosis and Related Disorders

Edwards KR, Garten L, Button J, O'Connor J, Kamath V and Frazier C.

Mult Scler Relat Disord. 2019 Mar 23;31:59-61.

DOI: 10.1016/j.msard.2019.03.016


Biomarkers may be a sensitive measure of disease activity in patients with multiple sclerosis (pwMS).


A pwMS had a marked increase of neurofilament light chain (NfL) in CSF 9-weeks prior to a clinical exacerbation.


Brain MRI, CSF, EDSS were measured at baseline, 6 weeks and 28 weeks. The patient had an exacerbation at week 15 of study but the NfL measured at week 6 were found to show a nearly 3-fold increase of CSF NfL levels prior to symptoms when the NfL levels were later measured.


This is an example supporting the usefulness of NfL in monitoring disease activity in pwMS which may predict disease activity prior to a clinical exacerbation.