Publications & Posters - Cardiology
Prospective Clinical Trial Measuring the Effects of Cardiopulmonary Bypass Under Mild Hypothermia on the Inflammatory Response and Regulation of Cold-Shock Protein RNA-Binding Motif 3.
Therapeutic hypothermia and temperature management | April 11, 2019
Rosenthal LM, Tong G, Wowro S, Walker C, Pfitzer C, Bottcher W, Miera O, Berger F and Schmitt KRL. Ther Hypothermia Temp Manag. 2019 Apr 11 DOI: 10.1089/ther.2018.0038 ABSTRACT
Point-of-Care Compatibility of Ultra-Sensitive Detection Techniques for the Cardiac Biomarker Troponin I-Challenges and Potential Value
Biosensors | December 06, 2018
Regan B, O'Kennedy R and Collins D Biosensors (Basel). 2018 Nov 21;8(4) DOI: 10.3390/bios8040114 ABSTRACT
Circulation | American Heart Association | November 14, 2017
Relations between elevated circulating cardiac troponin I (cTnI) levels and adverse cardiac outcomes were established prior to the advent of methods to measure extremely low levels of cTnI. Recently developed ELISA assays/platforms with ultra-high sensitivity cTnI (u-hs-cTnI) allow accurate…
Prognostic utility of neuroinjury biomarkers in post out-of-hospital cardiac arrest (OHCA) patient management
Medical Hypotheses | August 2017
Despite aggressive intervention, patients who survive an out-of-hospital cardiac arrest (OHCA) generally have very poor prognoses, with nationwide survival rates of approximately 10–20%.
Emerging Affinity-Based Proteomic Technologies for Large-Scale Plasma Profiling in Cardiovascular Disease
Circulation | April 24, 2017
Plasma biomarkers that reflect molecular states of the cardiovascular system are central for clinical decision making. Routinely used plasma biomarkers include troponins, natriuretic peptides, and lipoprotein particles, yet interrogate only a modest subset of pathways relevant to cardiovascular…
Nature Communications | December 2016
Interstitial fibrosis plays a key role in the development and progression of heart failure. Here, we show that an enzyme that crosslinks collagen-Lysyl oxidase-like 2 (Loxl2)-is essential for interstitial fibrosis and mechanical dysfunction of pathologically stressed hearts. In mice, cardiac stress…
Hospital Medicine Clinics | October, 2016
Troponin is an intracellular regulatory protein complex associated with the contractile apparatus of skeletal and cardiac myocytes. Irreversible injury of cardiac myocytes leading to cell death (myocardial necrosis) results in the release of cTnI and cTnT into the circulation. Highly specific…
Scientific Reports | May 31, 2016
Implementation of amyloid biomarkers in clinical practice would be accelerated if such biomarkers could be measured in blood. This study analyzes plasma levels of Aβ42 and Aβ40 in a cohort of 719 individuals using a ultrasensitive Simoa platform.
Circulation Research | September 15, 2015 | September 15, 2015
Our studies show that there is no age-related PCH in disease free 24-month-old C57BL/6 mice and that restoring GDF11 in old mice has no effect on cardiac structure or function.
Fully Automated Ultrasensitive Digital Immunoassay for Cardiac Troponin I Based on Single Molecule Array Technology
Clinical Chemistry | August 17, 2015
The association between increases in cardiac troponin and adverse cardiac outcomes is well established. There is a growing interest in exploring routine cardiac troponin monitoring as a potential early indicator of adverse heart health trends. Prognostic use of cardiac troponin measurements…