Publications & Posters - Cardiology
Observational study of long- term persistent elevation of neurodegeneration markers after cardiac surgery
Scientific Reports | May 09, 2019
DiMeglio M, Furey W, Hajj J, Lindekens J, Patel S, Acker M, Bavaria J, . Szeto WY, Atluri P, Haber M, Diaz-Arrastia R & Laudanski K. Sci Rep. 2019 May 9;9(1):7177. DOI: 10.1038/s41598-019-42351-2.
Prospective Clinical Trial Measuring the Effects of Cardiopulmonary Bypass Under Mild Hypothermia on the Inflammatory Response and Regulation of Cold-Shock Protein RNA-Binding Motif 3.
Therapeutic hypothermia and temperature management | April 11, 2019
Rosenthal LM, Tong G, Wowro S, Walker C, Pfitzer C, Bottcher W, Miera O, Berger F and Schmitt KRL. Ther Hypothermia Temp Manag. 2019 Apr 11 DOI: 10.1089/ther.2018.0038 ABSTRACT
Point-of-Care Compatibility of Ultra-Sensitive Detection Techniques for the Cardiac Biomarker Troponin I-Challenges and Potential Value
Biosensors | December 06, 2018
Regan B, O'Kennedy R and Collins D Biosensors (Basel). 2018 Nov 21;8(4) DOI: 10.3390/bios8040114 ABSTRACT
Circulation | American Heart Association | November 14, 2017
Relations between elevated circulating cardiac troponin I (cTnI) levels and adverse cardiac outcomes were established prior to the advent of methods to measure extremely low levels of cTnI. Recently developed ELISA assays/platforms with ultra-high sensitivity cTnI (u-hs-cTnI) allow accurate…
Emerging Affinity-Based Proteomic Technologies for Large-Scale Plasma Profiling in Cardiovascular Disease
Circulation | April 24, 2017
Plasma biomarkers that reflect molecular states of the cardiovascular system are central for clinical decision making. Routinely used plasma biomarkers include troponins, natriuretic peptides, and lipoprotein particles, yet interrogate only a modest subset of pathways relevant to cardiovascular…
Circulation Research | September 15, 2015 | September 15, 2015
Our studies show that there is no age-related PCH in disease free 24-month-old C57BL/6 mice and that restoring GDF11 in old mice has no effect on cardiac structure or function.
Tau proteins in serum predict neurological outcome after hypoxic brain injury from cardiac arrest: Results of a pilot study
Resuscitation | March, 2013
In this retrospective observational study, we employed a new ultra sensitive digital immunoassay technology to examine serial serum samples from 25 cardiac arrest patients to examine tau release into serum as a result of brain hypoxia, and probe for its significance predicting six-month…
Hospital Medicine Clinics | October, 2016
Troponin is an intracellular regulatory protein complex associated with the contractile apparatus of skeletal and cardiac myocytes. Irreversible injury of cardiac myocytes leading to cell death (myocardial necrosis) results in the release of cTnI and cTnT into the circulation. Highly specific…
A new ultra-high sensitivity troponin I assay for chest pain patients with no evidence of troponin I using a conventional assay
Clinical Biochemistry | December 4, 2014
There is considerable clinical interest in the development and possible implementation of highly sensitive cardiac troponin I (cTnI) assays for early rule out of acute coronary syndromes, short-term (30 days) risk stratification for future adverse cardiac events, and for detecting cardiac injury…
Prognostic utility of neuroinjury biomarkers in post out-of-hospital cardiac arrest (OHCA) patient management
Medical Hypotheses | August 2017
Despite aggressive intervention, patients who survive an out-of-hospital cardiac arrest (OHCA) generally have very poor prognoses, with nationwide survival rates of approximately 10–20%.