Publications & Posters - Cardiology
Observational study of long- term persistent elevation of neurodegeneration markers after cardiac surgery
Scientific Reports | May 09, 2019
DiMeglio M, Furey W, Hajj J, Lindekens J, Patel S, Acker M, Bavaria J, . Szeto WY, Atluri P, Haber M, Diaz-Arrastia R & Laudanski K. Sci Rep. 2019 May 9;9(1):7177. DOI: 10.1038/s41598-019-42351-2.
Prospective Clinical Trial Measuring the Effects of Cardiopulmonary Bypass Under Mild Hypothermia on the Inflammatory Response and Regulation of Cold-Shock Protein RNA-Binding Motif 3.
Therapeutic hypothermia and temperature management | April 11, 2019
Rosenthal LM, Tong G, Wowro S, Walker C, Pfitzer C, Bottcher W, Miera O, Berger F and Schmitt KRL. Ther Hypothermia Temp Manag. 2019 Apr 11 DOI: 10.1089/ther.2018.0038 ABSTRACT
Point-of-Care Compatibility of Ultra-Sensitive Detection Techniques for the Cardiac Biomarker Troponin I-Challenges and Potential Value
Biosensors | December 06, 2018
Regan B, O'Kennedy R and Collins D Biosensors (Basel). 2018 Nov 21;8(4) DOI: 10.3390/bios8040114 ABSTRACT
Circulation | American Heart Association | November 14, 2017
Relations between elevated circulating cardiac troponin I (cTnI) levels and adverse cardiac outcomes were established prior to the advent of methods to measure extremely low levels of cTnI. Recently developed ELISA assays/platforms with ultra-high sensitivity cTnI (u-hs-cTnI) allow accurate…
Emerging Affinity-Based Proteomic Technologies for Large-Scale Plasma Profiling in Cardiovascular Disease
Circulation | April 24, 2017
Plasma biomarkers that reflect molecular states of the cardiovascular system are central for clinical decision making. Routinely used plasma biomarkers include troponins, natriuretic peptides, and lipoprotein particles, yet interrogate only a modest subset of pathways relevant to cardiovascular…
Circulation Research | September 15, 2015 | September 15, 2015
Our studies show that there is no age-related PCH in disease free 24-month-old C57BL/6 mice and that restoring GDF11 in old mice has no effect on cardiac structure or function.
Fully automated ultrasensitive digital immunoassay for troponin using single molecule array technology
2015 American Association for Clinical Chemistry
P. Patel , D. Shan , L. Styskal , L. Chang , D. H. Wilson , M. J. Conrad , P. Jarolim Quanterix Corporation, Lexington, MA, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
PLoS One | December 14, 2011
Amyloid β (Aβ) peptides are proteolytic products from amyloid precursor protein (APP) and are thought to play a role in Alzheimer disease (AD) pathogenesis. While much is known about molecular mechanisms underlying cerebral Aβ accumulation in familial AD, less is known about the cause(s) of brain…
Scientific Reports | May 31, 2016
Implementation of amyloid biomarkers in clinical practice would be accelerated if such biomarkers could be measured in blood. This study analyzes plasma levels of Aβ42 and Aβ40 in a cohort of 719 individuals using a ultrasensitive Simoa platform.
Clinical Chemistry and Laboratory Medicine | October 22, 2014
Immunoassays measuring cardiac troponins I or T have become firmly established as critical tools for diagnosing acute myocardial infarction.