This study Investigates the association of plasma NFL with preclinical-AD features, such as high neocortical amyloid-β load (NAL) and subjective memory complaints, and cognitive performance in cognitively normal older adults.
Publications & Posters
Association of Plasma Neurofilament Light Chain with Neocortical Amyloid-β Load and Cognitive Performance in Cognitively Normal Elderly Participants
Journal of Alzheimer’s Disease | April 08, 2018
Plasma phospho-tau181 increases with Alzheimer’s disease clinical severity and is associated with tau- and amyloid-positron emission tomography
Alzheimer's & Dimentia | April 04, 2018
The goals of the present study using a novel assay for pTau were to examine and compare levels of plasma phospho-tau181 (pTau181) and plasma total tau by clinical diagnosis across the AD spectrum
Serum neurofilament light chain is a biomarker of acute and chronic neuronal damage in early multiple sclerosis
Multiple Sclerosis Journal | March 17, 2018
The objective of the study was to investigate the association between sNfL and clinical and MRI measurements in a therapy-naive cohort of CIS and RRMS patients in the very early stage of disease.
An analytical comparison of three immunoassay platforms for subpicomolar detection of protein biomarker GAD65.
PLOS One | March 08, 2018
The three methods tested allow sensitive detection of GAD65, but SIMOA appears best suited for automated quantification of subpicomolar concentrations.
Neurofilament light chain and tau concentrations are markedly increased in the serum of patients with sporadic Creutzfeldt-Jakob disease, and tau correlates with rate of disease progression
Journal of Neurology, Neurosurgery & Psychiatry | March 06, 2018
A blood-based biomarker of neuronal damage in sporadic Creutzfeldt-Jakob disease (sCJD) will be extremely valuable for both clinical practice and research aiming to develop effective therapies.
Journal of Neurology, Neurosurgery & Psychiatry | February 13, 2018
This study used an ultrasensitive single molecule methodology to measure plasma tau concentrations in 176 participants: 71 with bvFTD, 83 with PPA and 22 healthy controls.
Immunoassay methods used in clinical studies for the detection of anti-drug antibodies to adalimumab and infliximab
The Journal of Translational Immunology | February 12, 2018
The objective of this study was to examine the assay formats used to detect anti-drug antibodies (ADA) in clinical studies of the anti-TNF monoclonal antibodies adalimumab and infliximab in chronic inflammatory disease and their potential impact on pharmacokinetic and clinical outcomes.
Analytical Chemistry | February 09, 2018
This report describes a novel method for isolating and detecting individual enzyme molecules using polymer arrays of picoliter microwells.
Valproic Acid Treatment Decreases Serum GFAP and UCH‐L1 Levels in Swine Subjected to Traumatic Brain Injury
Journal of Neurotrauma | February 07, 2018
The primary aim of this study was to examine the effects of valproic acid (VPA) treatment on serum glial fibrillary acidic protein (GFAP) and neurofilament light chain (NF-L) levels.
Effects of Canagliflozin Versus Glimepiride on Adipokines and Inflammatory Biomarkers in Type 2 Diabetes
February 03, 2018
Type 2 diabetes and obesity are pro-inflammatory states associated with increased risk of cardiovascular disease.