Resources by Therapeutic Area
Rapid and ultrasensitive detection of botulinum neurotoxin serotype A1 in human serum and urine using single-molecule array method
Forensic Toxicology | September 2, 2016
Botulinum neurotoxin is one of the most poisonous substances ever known. It causes botulism, a persistent paralysis of peripheral nerve termini.
The Simoa p24 Antigen Assay is an ultra-sensitive digital immunoassay providing 1,000 times improvement in detection limits compared with a traditional ELISA. The method can be used to detect early reactivation of infectious virus from latent reservoirs and determine efficacy of drugs and therap
2016 Biomarkers & Diagnostics World Congress, Philadelphia, PA
Hepatitis B Virus (HBV) infection is still a serious global health problem and HBV infection is a leading cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma.
Inhibition of DPP4 activity in humans establishes its in vivo role in CXCL10 post-translational modification: prospective placebo-controlled clinical studies
EMBO Molecular Medicine | April 14, 2016
Biochemical experiments, animal models, and observational studies in humans all support a role of dipeptidyl peptidase 4 (DPP4) in the N-terminal truncation of CXCL10, which results in the generation of an antagonist form of the chemokine that limits T-cell and NK cell migration. This study highligh…
Ultrasensitive Detection and Quantification of Toxins for Optimized Diagnosis of Clostridium difficile Infection.
Journal of Clinical Microbiology | February 1, 2016
Recently developed ultrasensitive and quantitative methods for detection of Clostridium difficile toxins provide new tools for diagnosis and, potentially, for management of C. difficile infection (CDI). Compared to methods that detect toxigenic organism, ultrasensitive toxin detection may allow diag…