VCAM-1

Vascular Cellular Adhesion Molecule 1

VCAM-1 (Vascular Cellular Adhesion Molecule 1 also known as CD106) is a 110 kDa transmembrane glycoprotein expressed exclusively on cytokine-activated vascular endothelium. VCAM-1 protein mediates the adhesion of lymphocytes, monocytes, eosinophils, and basophils to vascular endothelium, and also functions in leukocyte-endothelial cell signal transduction. VCAM-1 has been shown to play an important role in the development of atherosclerosis and rheumatoid arthritis, and soluble VCAM-1 is a useful biomarker for many inflammatory diseases.