TSP-2 is a 150 kDa calcium-binding protein that regulates cellular interactions with extracellular matrix. TSP-2 is a potent inhibitor of tumor growth and angiogenesis. TSP-2 regulates collagen matrix formation by altering fibroblast behavior during development and in areas of tissue remodeling in the adult. TSP-2 is involved in cell adhesion and migration as well as modulating the cell surface properties of mesenchymal cells.


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