TNFβ

TNFβ

 

Tumor Necrosis Factor-beta (TNFβ), also known as Lymphotoxin-alpha (LT-α), is a member of the TNF superfamily. Human TNFβ is a 22 kDa protein that shares 73%amino acid sequence identity with mouse and rat TNFβ. Secreted TNFβ can form homotrimers that bind and activate multiple receptors. With membrane-localized LT-β, LT-α /TNFβ forms heterotrimers to bind and activate the LT-β R/TNFRSF3. TNF was initially identified for inducing necrosis in experimental cancers, but then a tumour promoting role was identified. TNFβ is expressed in activated T- and B- lymphocytes and contributes to autoimmune disease. TNFβ is found to mediate lymph node development, inflammation, and immune function.

Safety Data Sheets

The following Safety Data Sheets are associated with this Assay.