TNFα (non-human primate)

Tumor Necrosis Factor alpha (TNFα) is a polypeptide cytokine produced by monocytes and macrophages. The involvement of TNFα in several signal transduction pathways links the protein to such diverse functions as acute inflammation, apoptosis, septic shock, cellular proliferation, and differentiation. The clinical relevance of TNFα is from its association with numerous disease states including rheumatoid arthritis, cancer, cachexia, and Crohn’s disease.