Placental growth factor

Placental growth factor (PlGF) is a member of the vascular endothelial growth factor family (VEGF) and has been identified to have key roles in embryogenesis, angiogenesis, and vasculogenesis. PlGF is expressed by trophoblasts, particularly during pregnancy, and is also expressed at low levels in heart, lung, thyroid, and skeletal muscle. It has involvement in numerous pathologies including ischemic cardiovascular disease, skin wound healing, bone fracture repair, sepsis, colitis, liver cirrhosis, and arthritis.