Natriuretic peptides are produced primarily within the heart and released into the circulation in response to increased wall tension, reflecting increased volume or pressure overload. Under pathologic stimuli, the prohormone of BNP is synthesized, cleaved to BNP, the biologically-active peptide, and inactive fragment NT-proBNP, a 76aa amino terminal peptide. Both BNP and NT-proBNP are released predominantly by the ventricles in response to stretch, and are used for the diagnosis of systolic heart failure. NT-proBNP circulates at higher plasma concentrations and has a longer half-life when compared with BNP. Both peptides have proved equally useful for the diagnosis of ambulatory patients with heart failure and left ventricular dysfunction.
Simoa NT-proBNP Assay Kit