Neutrophil gelatinase-associated Lipocalin

Neutrophil gelatinase-associated Lipocalin (NGAL), also called Lipocalin-2, is expressed in neutrophils and normally produced at low levels by epithelial cells, kidney tubular cells and in case of injury or inflammation by hepatocytes. Increased NGAL expression is seen in cases of damage of epithelial cells of the kidneys, large intestine, liver and lungs. NGAL is is one of the most widely studied biomarkers for Acute Kidney Injury, and NGAL formation is induced in many human tumors and is a predictor of poor prognosis.