The Simoa Human Neurology 4-Plex E (N4PE) assay simultaneously measures four biomarkers in EDTA plasma and CSF. The targets are Abeta 40 (Aβ40), Abeta 42 (Aβ42), Glial Fibrillary Acidic Protein (GFAP), and Neurofilament light (NF-L). Each biomarker has been demonstrated to have significance for the investigation of neurodegeneration and brain injury, and to have utility for monitoring effectiveness of drug discovery and development for neurological disease.
With this Neuro 4-Plex E kit for HD-X, we introduce novel Abeta 40 and Abeta 42 assays developed for highly specific and sensitive measurement of the concentrations of full length Abeta1-42 and Abeta1-40. This improved specificity for full-length Abeta1-42 and Abeta1-40 is expected to be increasingly important for monitoring the effect of treatments that target specific Abeta isoforms and for target engagement in future clinical trials.