Human MMP-9

Matrix metalloproteinase 9 (MMP-9) is a 92 kDa secreted protein, belonging to the metzincin (multi domain zinc (II) dependent endopeptidases) superfamily of proteases. It is produced by normal and transformed cells. MMP-9 functions through enzymatic degradation by cleaving extracellular matrix proteins and adhesion molecules (like ICAM-5). These events play major roles in the processes of synaptic plasticity, learning, memory, and morphological reconstruction of targets such as neuronal dendritic spines. MMP-9 has been shown to be linked to various disease states including cancer, cardiovascular disease and arthritis. Specifically, cancer models have shown directly that metastasis/angiogenesis and overall tumor aggression are linked to elevated MMP-9 levels. Cardiovascular issues including myocardial infarction, aneurysms, and atherosclerotic plaques have been shown to be linked to increased MMP-9 levels using knockout and overexpression studies in mice. Allograft studies of renal transplant patients have unearthed links between MMP-9 and immune-mediated tissue rejection (destruction) of the allograft opening up windows for rejection prediction in future transplant cases.

Safety Data Sheets

The following Safety Data Sheets are associated with this Assay.

Certificates of Analysis

The following Certificates of Analysis are associated with this Assay.

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