IL-4

IL-4

Human Interleukin-4 (IL-4) is a monomeric cytokine, approximately 13-18 kDa, expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils. IL-4 has a compact, globular fold (similar to other cytokines) stabilized by 3 disulphide bonds. Mature human IL-4 shares 55%, 39%, and 43% amino acid sequence identity with bovine, mouse, and rat IL-4, respectively. By binding to IL-4 receptor or receptor complex, IL-4 has many biological functions. It promotes cell proliferation, survival, and immunoglobulin class switch to IgG4 and IgE in human B cells, acquisition of the Th2 phenotype by naïve CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL-4 plays an important role in the development of allergic inflammation and asthma.

Safety Data Sheets

The following Safety Data Sheets are associated with this Assay.

Certificates of Analysis

The following Certificates of Analysis are associated with this Assay.