IL-23

IL-23

Interleukin 23 (IL-23) is a heterodimeric cytokine composed of the IL-12 p40 “soluble receptor” subunit and a novel cytokine-like subunit related to IL-12 p35, termed p19. Like IL-12, IL-23 binds to the IL-12R subunit IL-12Rβ1. However, it does not use IL-12Rβ2. IL-23 stimulates IFN-γ production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells. Activated dendritic cells secrete detectable levels of IL-23. IL-23 promotes inflammatory responses such as upregulation of the matrix metalloprotease MMP9, and increases angiogenesis but reduces CD8 T-cell infiltration. Studies have indicated that IL-23 is an important molecular link between tumor-promoting pro-inflammatory processes and the failure of the adaptive immune surveillance to infiltrate tumors.

Safety Data Sheets

The following Safety Data Sheets are associated with this Assay.

Certificates of Analysis

The following Certificates of Analysis are associated with this Assay.