IL-17A/F (mouse)

mouse IL-17A/F

Mouse Interleukin17A/F is a heterodimer contains two subunits A and F. IL-17A subunit has 158 amino acids (molecular weight 21 kDa), IL-17F subunit has 50% similarity to A. All IL-17 cytokines have a similar protein structure, and no sequence similarity to any other cytokines. These cytokines are well conserved in mammals, with significant sequence conservation between the human and mouse homologs. A major role of IL-17 is its involvement in inducing and mediating proinflammatory responses. It acts as potent mediator in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to interferon gamma. IL-17 is produced by T-helper cells and is induced by IL–23 which results in destructive tissue damage in delayed-type reactions. IL-17 induces the production of many other synergistic cytokines, including GM-CSF, IL-6, IL-1b, and TNFa. The IL-17 family has been linked to many immune/autoimmune related diseases including rheumatoid arthritis, asthma, lupus, allograft rejection, anti-tumor immunity and recently Psoriasis. Because of its involvement in autoimmune conditions, IL-17 inhibitors are being investigated as possible treatments.

Safety Data Sheets

The following Safety Data Sheets are associated with this Assay.

Certificates of Analysis

The following Certificates of Analysis are associated with this Assay.