Intercellular adhesion molecule-1

Intercellular adhesion molecule-1 (ICAM-1; also known as CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and plays a central role in leukocyte trafficking, activation of lymphocytes, and numerous additional immune functions. ICAM-1 is constitutively expressed on many immune, endothelial and epithelial cell types, and its expression is upregulated in inflammatory conditions, specifically by TNF-α, IL-1β, IFN-γ and other cytokines.  By interacting with lymphocyte function associated molecule (LFA)-1 and others, ICAM-1 acts as a leukocyte adhesion molecule.  ICAM-1 is highly expressed in inflammatory conditions, chronic diseases and a number of malignancies.