Cytokine 3-Plex B TNFα, IL-6, IL-17A

Cytokine 3-Plex B TNFα, IL-6, IL-17A

Human tumor necrosis factor alpha (TNFα) is a homotrimeric transmembrane protein that functions as a proinflammatory cytokine. It is produced mainly by macrophages but also by a variety of other cell types, including monocytes, neutrophils, and T-cells. The involvement of TNFα in several signal transduction pathways links the protein to such diverse functions as acute inflammation, apoptosis, septic shock, cellular proliferation, and differentiation. Human TNFα is a non-glycosylated protein of 157 amino acids, with a molecular weight of approximately 17,000 daltons. The clinical relevance of TNFα stems from its association with numerous disease states including rheumatoid arthritis, cancer, cachexia, and Crohn’s disease.

Certificates of Analysis

The following Certificates of Analysis are associated with this Assay.