CXCL13 (BCA-1)


The CXCL13 (CXC Ligand 13) protein, also known as B cell attracting chemokine 1 (BCA-1) or B lymphocyte chemo-attractant (BLC) is a chemokine ligand. It is expressed in secondary lymphoid tissue by stromal cells within B-cell follicles and by follicular dendritic cells, macrophages, and germinal center T cells. The CXCL13 receptor CXCR5 is expressed on follicular B cells. CXCL13 interaction with its receptor causes germinal center formation as part of a normal immune response to infection. The main role of CXCL13 is homeostatic immune cell trafficking and levels may become up-regulated under pathological conditions. CXCL13 and CXCR5 are expressed in prostrate, breast, neuronal and oral carcinomas. Elevated serum CXCL13 levels have been observed in lung cancer and breast cancer patients.

Safety Data Sheets

The following Safety Data Sheets are associated with this Assay.

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