Alzheimer’s & Dementia | May 5, 2021
Gold BT, Shao X, Sudduth TL, Jicha GA, Wilcock DM, Seago ER and Wang DJJ
Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2021
DOI: https://doi.org/10.1002/alz.12357
Abstract
Introduction
We tested if water exchange across the blood-brain barrier (BBB), estimated with a noninvasive magnetic resonance imaging (MRI) technique, is associated with cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease (AD) and neuropsychological function.
Methods
Forty cognitively normal older adults (67–86 years old) were scanned with diffusion-prepared, arterial spin labeling (DP-ASL), which estimates water exchange rate across the BBB (kw). Participants also underwent CSF draw and neuropsychological testing. Multiple linear regression models were run with kw as a predictor of CSF concentrations and neuropsychological scores.
Results
In multiple brain regions, BBB kw was positively associated with CSF amyloid beta (Aβ)42 concentration levels. BBB kw was only moderately associated with neuropsychological performance.
Discussion
Our results suggest that low water exchange rate across the BBB is associated with low CSF Aβ42 concentration. These findings suggest that kw may be a promising noninvasive indicator of BBB Aβ clearance functions, a possibility which should be further tested in future research.
This study was performed using the Quanterix HD-1 Analyzer.
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