THE JOURNAL OF HEAD TRAUMA REHABILITATION
Pattinson CL, Shahim P, Taylor P, Dunbar K, Guedes VA, Motamedi V, Lai C, Devoto C, Peyer J, Roy MJ and Gill JM.
J Head Trauma Rehabil. 2019 Apr 25.
DOI: 10.1097/HTR.0000000000000485
Abstract
Objective:
To understand the relationships between traumatic brain injury (TBI), blood biomarkers, and symptoms of posttraumatic stress disorder (PTSD), depression, and postconcussive syndrome symptoms.
Design:
Cross-sectional cohort study using multivariate analyses.
Participants:
One hundred nine military personnel and veterans, both with and without a history of TBI.
Main Measures:
PTSD Checklist-Civilian Version (PCL-C); Neurobehavioral Symptom Inventory (NSI); Ohio State University TBI Identification Method; Patient Health Questionnaire-9 (PHQ-9); Simoa-measured concentrations of tau, amyloid-beta (Aβ) 40, Aβ42, and neurofilament light (NFL).
Results:
Controlling for age, sex, time since last injury (TSLI), and antianxiety/depression medication use, NFL was trending toward being significantly elevated in participants who had sustained 3 or more TBIs compared with those who had sustained 1 or 2 TBIs. Within the TBI group, partial correlations that controlled for age, sex, TSLI, and antianxiety/depression medication use showed that tau concentrations were significantly correlated with greater symptom severity, as measured with the NSI, PCL, and PHQ-9.
Conclusions:
Elevations in tau are associated with symptom severity after TBI, while NFL levels are elevated in those with a history of repetitive TBIs and in military personnel and veterans. This study shows the utility of measuring biomarkers chronically postinjury. Furthermore, there is a critical need for studies of biomarkers longitudinally following TBI.
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