Development of a Spatial Metabolic Map of Immunotherapy Sensitive and Resistant Cutaneous Skin Carcinoma
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Ultrahigh-Plex Single-cell Spatial Phenotyping has revealed valuable insights into the tumor immune microenvironment (TiME) for biomarker discovery and stratification of clinical responses. Metabolic reprogramming is a key hallmark of cancer and plays an important role in tumor progression, immune activation and metastasis. Here, we investigated the metabolic and immune landscape of cutaneous squamous cell carcinoma (cSCC) with the PhenoCycler®-Fusion, an end-to-end integrated spatial biology platform with single-cell resolution and rapid turnaround time.
Explore our off-the-shelf Human Metabolism Spike-In Module for spatial profiling of metabolic states across diverse cell populations. The module is designed for seamless integration into the Human IO60 PhenoCode Discovery Panel for comprehensive profiling of the TiME at single-cell resolution.
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