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Overcoming Multiplex Immunoassay Hurdles


Tracking multiple targets in one reaction is an increasing requirement of assays being used in molecular biology and medicine. Optimally, scientists want to analyze as many biological or molecular markers as possible in the same experiment to acquire better comparisons of shifts in the patterns of different targets associated with changes in different biological processes. Such multiplexing saves time and sample volumes, some of which can be precious and difficult to obtain. Tracking these molecules often involves antibody-based chemistries. Add those two things together, and you get multiplex immunoassays.

Many applications can benefit from multiplexing technologies. According to Scott Van Arsdell, vice president of immunoassay technology at Aushon Biosystems, the major applications of multiplex immunoassays include clinical trials, toxicity testing, translational research, therapeutic monitoring and diagnosis of complex diseases.

Dandan Shan, senior scientist at Quanterix, adds, “The capabilities of the multiplex technology are particularly well-suited for pharmacodynamics and pharmacokinetic characterizations of candidate drug therapies, because they allow researchers to directly quantify the biochemical impact of a drug.”

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