To determine if blood neurofilament light chain (NfL) protein can discriminate between Parkinson disease (PD) and atypical parkinsonian disorders (APD) with equally high diagnostic accuracy as CSF NfL, and can therefore improve the diagnostic workup of parkinsonian disorders.
Cell Reports | January 31, 2017
The presence of latent HIV-1 in infected individuals represents a major barrier preventing viral eradication. For that reason, reactivation of latent viruses in the presence of antiretroviral regimens has been proposed as a therapeutic strategy to achieve remission.
Ultrasensitive HIV-1 p24 detects single infected cells and differences in reservoir induction by latency-reversal agents
Journal of Virology | January 11, 2017
Here, we used an ultrasensitive p24 digital assay, which we report to be 1000 fold more sensitive than classical ELISA in the quantification of HIV-1 Gag p24 production in HIV-infected individuals samples.
Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic
Alzheimer's & Dementia | January 13, 2017
The last decade has seen a substantial increase in research focused on the identification of blood-based biomarkers that have utility in Alzheimer's disease (AD). Blood-based biomarkers have significant advantages of being time- and cost-efficient as well as reduced invasiveness and increased…
Neurology | January 6, 2017
Despite the 3.8 million sports-related concussions (SRC) that occur annually in the United States, there are currently no prognostic biomarkers to predict recovery and an athlete’s readiness to return to play (RTP). An objective predictor of recovery time in the acute aftermath of SRC would provide…
Increases of Plasma Levels of Glial Fibrillary Acidic Protein, Tau, and Amyloid β up to 90 Days after Traumatic Brain Injury
Journal of Neurotrauma | January 1, 2017
Glial fibrillary acidic protein (GFAP), microtubule-associated protein tau, and amyloid β peptide (Aβ42) have been proposed as diagnostic and prognostic biomarkers in traumatic brain injury (TBI). Single molecule array (Simoa) is a novel technology that employs highly sensitive immunoassays for…
Journal of the American Chemical Society | December 22, 2016
Sarah J. Smith, Carine R. Nemr, and Shana O. Kelley JACS- Journal of the American Chemical Society DOI: 10.1021/jacs.6b10850 Download Paper
Alzheimer's and Dementia | December 19, 2016
•Compared with controls, plasma total tau (t-tau) ≥3.56 was 100% specific to former NFL players. •Greater repetitive head impact exposure predicts higher later-life plasma t-tau. •Further study on plasma t-tau as a screening biomarker for chronic traumatic encephalopathy is warranted.
A digital enzyme-linked immunosorbent assay for ultrasensitive measurement of amyloid-β 1–42 peptide in human plasma with utility for studies of Alzheimer’s disease therapeutics
Alzheimer's Research & Therapy | December 15, 2016
The digital ELISA developed in this study provided sensitive and precise measurement of plasma Aβ1–42 in clinical samples treated with the BACE1 inhibitor LY2886721. The improved assay sensitivity enabled Aβ1–42 to be reliably quantified even at low picogram-per-milliliter levels.