Tauopathies are a group of disorders in which the cytosolic protein tau aggregates and accumulates in cells within the brain, resulting in neurodegeneration. A promising treatment being explored for tauopathies is passive immunization with anti-tau antibodies.
Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy
Science Translational Medicine | April 19, 2017
The Journal of Experimental Medicine | April 18, 2017
Type I interferons (IFNs) are essential mediators of antiviral responses. These cytokines have been implicated in the pathogenesis of autoimmunity, most notably systemic lupus erythematosus (SLE), diabetes mellitus, and dermatomyositis, as well as monogenic type I interferonopathies.
Science Translational Medicine | April 17, 2017
Tauopathies are characterized by the progressive accumulation of hyperphosphorylated, aggregated forms of tau. Our laboratory has previously demonstrated that passive immunization with an anti-tau antibody, HJ8.5, decreased accumulation of pathological tau in a human P301S tau-expressing transgenic…
Neurology | April 12, 2017
The results from these 2 independent cohort studies suggest that serum NFL is a highly sensitive biomarker for concussion.
Current AIDS/HIV Report April 11, 2017
The development and evaluation of strategies for HIV remission rely upon our ability to accurately and precisely quantify the size of the remaining viral reservoir.
Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10
The Journal of Immunology | April 7, 2017
In this study, we report that oral administration of a selective ROCK2 inhibitor, KD025, reduces psoriasis area and severity index scores by 50% from baseline in 46% of patients with psoriasis vulgaris, and it decreases epidermal thickness as well as T cell infiltration in the skin.
Rhodopsin in plasma from patients with diabetic retinopathy – development and validation of digital ELISA by Single Molecule Array (Simoa) technology
Journal of Immunological Methods | April 5, 2017
The aim of this study was to develop and validate a Rhodopsin assay by employing digital ELISA technology, and to investigate whether Rhodopsin concentrations in diabetes patients with DR are elevated compared with diabetes patients without DR.
Transient HIV-specific T cells increase and inflammation in an HIV-infected patient treated with nivolumab
AIDS | April 24, 2017
So far, two case reports involving HIV-infected patients with melanoma treated with ICIs have shown encouraging safety results but distinct viral effects.
The 5th Annual One Mind Summit: Lessons Learned About “Science Informing Brain Health Policies and Practice”
Journal of Neurotrauma | March 29, 2017
Abstract Advances in science frequently precede changes in clinical care by several years or even decades. To better understand the path to translation, we invited experts to share their perspectives at the 5th Annual One Mind Summit
JAMA Neurology | March 27, 2017
Biomarkers based on standard blood test results would be useful in research, drug development, and clinical practice. Plasma neurofilament light (NFL) has recently been proposed as a blood-based biomarker for neurodegeneration in dementias.