In this study, we investigated the molecular mechanisms dictating the interactions between human MAIT cells and DCs and demonstrate that human MAIT cells mature monocyte-derived and primary DCs in an MR1- and CD40L-dependent manner.
Publications & Posters
Activation of Human Mucosal-Associated Invariant T Cells Induces CD40L-Dependent Maturation of Monocyte-Derived and Primary Dendritic Cells
The Journal of Immunology | September 6, 2017
Bioanalysis | May 10, 2017
Ligand-binding techniques such as immunoassays, the reference for clinical diagnosis, offer a wide range of innovative approaches based on signal DNA amplification, nanotechnologies or digital assays, which result in technologies with sensitivities more than 1000-times that of formats used 20 years…
Genetic Engineering & Biotechnology News| February 15, 2017
Tumor biomarkers act as important contextual cues or signals of cancer status.
Personalized peptide vaccine-induced immune response associated with long-term survival of a metastatic cholangiocarcinoma patient
Journal of Hepatology | July 2016
Metastatic cholangiocarcinomas, cancers that originate from the liver bile ducts, have very limited treatment options and a fatal prognosis. We describe a novel therapeutic approach in such a patient using a personalized multi-peptide vaccine. This vaccine, developed based on the characterization…
Do Ultrasensitive Prostate Specific Antigen Measurements Have a Role in Predicting Long-Term Biochemical Recurrence-Free Survival in Men after Radical Prostatectomy?
Journal of Urology | February 2016
In this study we evaluate an ultrasensitive prostate specific antigen assay in patients with prostate cancer after radical prostatectomy to predict long-term biochemical recurrence-free survival.
Analytical Chemistry | February 2, 2016
The cell is the basic unit of biology and protein expression drives cellular function. Tracking protein expression in single cells enables the study of cellular pathways and behavior, but requires methodologies sensitive enough to detect low numbers of protein molecules with a wide dynamic range to…
Scientific Reports | June 8, 2015
Current technologies for cancer screening and detection typically rely on imaging techniques or blood tests that are not accurate or sensitive enough to definitively diagnose cancer at its earliest stages or predict biologic outcomes. By utilizing Single Molecule Arrays (SiMoA), an ultra-sensitive…
Analyzing polyubiquitin chains upon ubiquitin activating enzyme inhibition from cell culture & tumor lysates using the Quanterix's single molecule array (Simoa) technology.
2013 Society for Laboratory Automation & Screening Annual Meeting, Orlando, FL
Ubiquitination is a post-translational modification process which involves the attachment of ubiquitin(Ub) to lysine residues on either substrate proteins or itself resulting in protein monoubiquitination or polyubiquitination.
Fifth-Generation Digital Immunoassay for Prostate-Specific Antigen by Single Molecule Array Technology
Clinical Chemistry | October 13, 2011
Measurement of prostate-specific antigen (PSA) in prostate cancer patients following radical prostatectomy (RP) has been hindered by the limit of quantification of available assays. We developed an investigational digital immunoassay with a limit of quantification 2 logs lower than current…
Clinical Evaluation of a Novel Method for Measurement of PSA, AccuPSA™, as a Predictor of 5-year Biochemical Recurrence-free Survival Post Radical Prostatectomy: Results of a Pilot Study
BJU International | October 12, 2011
Nadir Ultrasensitive PSA levels has some value for predicting BCR following RD.